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DOCUMENTS
Antibody Engineering
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Fcab Antibody Engineering Lecture
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Combinatorial antibody libraries: new advances, new immunological insights [Nature Reviews Immunology 16, 498–508 (2016)]
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Construction of pH-sensitive Her2-binding IgG1-Fc by directed evolution [Biotechnol. J. 2014, 9, 1013–1022]
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Engineered IgG1-Fc – one fragment to bind them all [Immunological Reviews 2016 Vol. 270: 113–131]
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Creating stable stem regions for loop elongation in Fcabs — Insights from combining yeast surface display, in silico loop reconstruction and molecular dynamics simulations [Biochimica et Biophysica Acta 1844 (2014) 1530–1540]
E. coli expreesion
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SHuffle, a novel Escherichia coli protein expression strain capable of correctly folding disulfide bonded proteins in its cytoplasm [Microbial Cell Factories 2012, 11:56]
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Efficient expression of full-length antibodies in the cytoplasm of engineered bacteria [Nature Communcations, 2-16, 6:8072]
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Use of the SHuffle Strains in Production UNIT 5.26 of Proteins [Current Protocols in Protein Science, 2016, 5.26.1-5.26.21]
Affinity Scaffold
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Design principles for reagentless biosensors: specific fluorophore/analyte binding and minimization of fluorophore/scaffold interactions [Journal of Molecular Biology, 2016, manuscript accepted]
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Activity-based assessment of an engineered hyperthermophilic protein as a capture agent in paper-based diagnostic tests [Molecular Systems Design & Engineering, 2016]
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